Generative AI & Protein Engineering
Combining our unprecedented database with advanced AI to engineer next-generation gene editing systems for previously untreatable diseases.
// Generative AI &
Protein Engineering
Unlocking Discovery with the Industry’s Largest CRISPR Dataset
We have one of the industry’s largest CRISPR collections, featuring millions of sequences and a catalog of more than 20 billion proteins and growing. This data-rich foundation gives our scientists a unique advantage in rapidly identifying novel targets that others miss, cutting months from traditional discovery timelines.
AI-Powered CRISPR Design
Our sophisticated protein language models analyze vast datasets to uncover new CRISPR systems beyond what traditional methods could identify. Through our multi-year collaboration with Amazon Web Services (AWS), we train and execute these models at scale. By combining generative AI with our proprietary experimental data, we can predict, design, and optimize both naturally occurring and synthetic CRISPR proteins with unprecedented precision.
Expanding Gene Editing’s Therapeutic Reach
We’re taking on the challenge of expanding CRISPR’s application beyond the small number of single-gene conditions addressed by first-generation therapies. Our AI-driven approach is accelerating development for thousands of more complex monogenic disorders as well as polygenic diseases, paving the way for potentially curative treatments across a much broader range of therapeutic areas. Where others see limitations, we see opportunities to engineer synthetic solutions tailored for each disease.
Precision Optimization at Scale
Our platform systematically addresses key challenges in CRISPR development: editing efficiency, target specificity, tissue delivery, and off-target activity. Through our AWS collaboration, we combine PLM-driven active learning with targeted experimental screens – including DNA binding, nuclease activity, base editing, reverse transcriptase editing, and off-target analysis – to optimize protein performance. This approach allows us to rapidly iterate designs and explore a wider design space than conventional methods, significantly reducing both time and cost of protein discovery while improving therapeutic potential.
Elevated Insights
From gene editing to biomanufacturing, learn more about the cell and gene therapy industry from our team of industry-leading experts.
Partner with ElevateBio®
Wherever you are in your advanced therapy product lifecycle, we can strengthen and accelerate your development journey with our enabling technologies and unmatched process development and manufacturing capabilities.
// Work with us
