Versatile and robust epigenetic modulation platform for programmable gene activation and repression

Epigenetic editing enables precise control of gene expression without altering the underlying DNA sequence. This approach opens the possibility of developing genomic medicines for broader therapeutic applications, beyond monogenic diseases. In addition, when delivered by LNP, the up- or down-regulation of gene expression is reversible, as the editing does not permanently alter the genome. We demonstrate ElevateBio’s robust and tunable epigenetic editing platform for programmable gene modulation using novel RNA-guided epigenetic repressors and activators