Leveraging generative AI to design novel, functional deaminases for adenine base editing​

Generative AI is a powerful tool for designing novel proteins, including deaminases for adenine base editing, transcending natural evolutionary constraints to create truly new and highly active deaminases. Using this approach at ElevateBio, we have identified an AI-generated candidate that achieved >20% on-target A→G editing efficiency with exceptional precision (<1.0% bystander effects), solving key specificity challenges in base editing. Our integrated creation/optimization platform, powered by our extensive protein catalog and depth of experimental data, establishes a novel workflow for designing therapeutic proteins tailored to specific applications.