Next-Generation Sequencing: Expert Analysis, Rapid Results
Getting actionable answers from sequencing data requires more than an instrument and a turnaround time. ElevateBio’s Sequencing Core provides the scientific expertise that turns raw data into program decisions. The only Twist NGS Pro Lab in New England, the Sequencing Core runs Illumina, Oxford Nanopore, and 10x Genomics platforms with automated bioinformatics and expert consultation from study design through data delivery.
// Manufacturing &
Development Services
Only
- Twist NGS Pro Lab in New England
<1
- Week turnaround for amplicon sequencing
2-4
- Weeks faster for advanced assays
When Sequencing Data Needs to Drive a Decision, Context Matters
The difference between sequencing data and a program decision is the scientist interpreting it. ElevateBio’s Sequencing Core employs scientists with deep experience in panel design, assay optimization, and data interpretation, consulting on study design from the start, not just processing samples at the end. For ElevateBio manufacturing partners, sequencing results connect directly to the process development teams. Standalone clients access the same depth from the first conversation.
Adriana Geldart, Ph.D.
Senior Director, Next-Generation Sequencing
Most Sequencing Projects Wait Weeks for Results. Yours Don’t Have to.
Advanced sequencing assays often take weeks through external vendors. ElevateBio’s Sequencing Core runs the same applications 2-4 weeks faster than typical external vendor timelines, with amplicon workflows returning results in under one week. That speed comes from optimized protocols and assay controls, automated bioinformatics pipelines built on Nextflow, and a focused team built around advanced therapy and research applications.
| Sequencing Type | Platforms |
|---|---|
| Amplicon | Illumina, Oxford Nanopore |
| Whole Genome | Illumina |
| Whole Exome | Illumina |
| RNA (including Single-Cell) | Illumina, 10x Genomics |
| Complete Plasmid | Oxford Nanopore |
| Methylation | Illumina |
The Sequencing Core serves two types of programs
Cell and gene therapy characterizationVector genome analysis, insertion site mapping, and CRISPR on/off-target assessment |  |
Research and translational applicationsCustom capture panel design, high-throughput RNA workflows, and full analytical and bioinformatics reporting |  |
All pipelines deploy on AWS, returning processed data in days rather than weeks.
To discuss which sequencing type fits your program, talk to our team.
Cell Therapy Release Testing Still Relies on Three Separate Assays. That Is Changing.
The standard cell therapy safety release panel requires sterility testing, mycoplasma testing, and adventitious agent testing. Three separate assays, each with its own timeline, its own failure modes, and its own cost.
While ElevateBio’s current sequencing services are for characterization, the Sequencing Core anchors an active development program working toward a single NGS-based multiplexed assay to replace that panel. For programs evaluating how sequencing fits into their release strategy, the Analytical Development page has the detail.
Resources
ElevateBio’s Next-Generation Sequencing Core: Meeting the Challenges of Cost, Time and Data Quality with Expertise and Collaboration
Sequencing-based analytics offer potential for rapid sterility and adventitious agent testing
Frequently Asked Questions
What next-generation sequencing services does ElevateBio offer?
ElevateBio offers amplicon, whole genome, whole exome, RNA including single-cell, complete plasmid, and methylation sequencing on Illumina, Oxford Nanopore, and 10x Genomics platforms. The team also provides custom panel design, optimized assay controls, automated bioinformatics, and analytical reporting tailored to each program’s needs. Current services are for characterization.
How fast is ElevateBio's NGS turnaround time?
Amplicon sequencing workflows return results in under one week. Advanced assays are delivered 2 to 4 weeks faster than typical external vendor timelines, supported by optimized protocols and automated Nextflow pipelines that deploy on AWS.
Does ElevateBio offer NGS services outside of manufacturing partnerships?
Yes. The ElevateBio Sequencing Core is available as a contract or outsourced sequencing service to cell and gene therapy developers, academic research groups, and translational teams, with no manufacturing engagement required.
What is a Twist NGS Pro Lab and why does it matter?
The Twist NGS Pro Lab designation identifies laboratories that consistently deliver results using Twist Bioscience’s target enrichment solutions. ElevateBio is the only designated Twist NGS Pro Lab in New England, giving Northeast programs direct access to Twist’s target enrichment chemistry alongside ElevateBio’s bioinformatics and reporting capabilities.
Ready to Talk
Need sequencing support for a single project or want to understand how NGS fits a larger program? Talk to our team.
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