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ElevateBio

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Lentiviral Vector Development & GMP Manufacturing

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The LentiPeak™ Platform

Our proprietary lentiviral vector (LVV) platform is customized to meet your specific development needs.

We offer our partners a suspension-based, scalable lentiviral vector production platform.

Speed

Streamlined Tech Transfer between PD and cGMP manufacturing with aligned unit operations, equipment, bill of materials and analytics 

Available cGMP capacity without waiting time

Parallel development with cell processing activities for ex-vivo programs

Control Strategies

Efficient supply chain management & risk mitigation

Comprehensive regulatory support package

Integrated analytical support with panels of established testing methods in-house

Expertise

Process utilizes a 4-plasmid 3rd gen LV system and a HEK 293 suspension cell line

Pre-established cGMP documentation and trained technical team

Proven platform performance with various CAR and TCR constructs at multiple production scales

LentiPeak™ Platform: Process Overview

Process

  • HEK293 cell line
  • Suspension based, serum free
  • Transient Transfection

System

  • 3rd Generation LV plasmid system
  • Accommadates a large range of GOI sizes
  • Supporting analytics

Productivity

  • High functional titers
  • 1.00E+08 to 1.00+09 TU/mL

Learn More About our Work in Lentiviral Vector Development

Elevate Insights whitepaper on our LVV capabilities

Read whitepaper

BioPharm International publication on the strategies and tactics for designing an ideal lentiviral vector platform

Review publication

Poster on our lentiviral vector platform presented at the fall 2022 BioProcess International Conference

View poster

“De-risking lentiviral vector production using a robust, scalable, suspension-based platform” webinar

Watch webinar

LentiPeak® fact sheet

See factsheet

ElevateBio BaseCamp®

Where the Innovation Happens

BaseCamp is the innovation engine where technology, expertise, operations, processes, and GMP manufacturing come together to overcome industry challenges and accelerate the development of advanced therapies.

Learn More about BaseCamp®

Watch the BaseCamp® Overview Video

Basecamp

Cell Platform Manufacturing Processes
Vector Platform Manufacturing Processes
Process Development & Analytics
Manufacturing & Automation
Cell Platform Manufacturing Processes

Cell Platform Manufacturing Processes

  • Cell therapy process tools and equipment
  • Platform processes for CAR-T and TCR-T
  • Modular unit operations to accommodate multiple cell types
Vector Platform Manufacturing Processes

Vector Platform Manufacturing Processes

  • Suspension-based upstream process for LVV and AAV
  • Platform upstream & downstream lentiviral process for CAR-T, TCR-T and in vivo lenti viral vectors
  • Wide array of vector services
Process Development & Analytics

Process Development & Analytics

  • Industry leading Process Development expertise
  • Directly scalable processes from PD to GMP
  • Process optimization with scale up/down models
  • State of the art, in-house rapid QC release test methods and analytics
Manufacturing & Automation

Manufacturing & Automation

  • End-to-end solutions for cGMP manufacturing
  • Multiple automated systems for real-time review of data and product release
  • CMC regulatory support
  • Aphoresis support

How can we support your project goals?

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    • End-to-End Capabilities Overview
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